Although occupational transmission of drug-resistant HIV strains has been reported despite PEP with combination drug regimens 36,the effect of exposure to a resistant virus on transmission and transmissibility is not well understood.
Recommendations on the management of occupational exposures to hepatitis B virus or hepatitis C virus have been published previously 3 and are not included in this report. Although rare instances of delayed HIV seroconversion have been reported, the infrequency of this occurrence does not warrant adding to the anxiety level of the exposed persons by routinely extending the duration of postexposure follow-up.
Confidentiality of source patients and exposed HCWs was maintained at all levels. This updates the review of scientific evidence on the safety and efficacy of daily oral antiretroviral HIV preexposure prophylaxis PrEP.
Occupational exposure to bloodborne pathogens; final rule.
When HBIG is indicated, it should be administered as soon as possible after exposure preferably within 24 hours. Procedures should be followed for testing source persons, including obtaining informed consent, in accordance with applicable state and local laws. Updated guidelines for antiretroviral postexposure prophylaxis after sexual, injection drug use, or other nonoccupational exposure to HIV—United States, Updates and expands the U.
Federal Register ; Present study includes data from 14 ARTCs.
No clinical trials have been conducted to assess postexposure use of antiviral agents e. Recent reports of fatal and nonfatal lactic acidosis in pregnant women treated throughout gestation with a combination of d4T and ddI have prompted warnings about use of these drugs during pregnancy HCPs should be educated to report occupational exposures immediately after the occurrence, particularly because hepatitis B vaccine and HIV - PEP is most effective if administered soon after the exposure.
How should HIV exposures in lactating exposed persons be managed? In addition, occupational transmission of resistant HIV strains, despite PEP with combination drug regimens, has been reportedThe addition of a third drug for PEP after a high-risk exposure is based on demonstrated effectiveness in reducing viral burden in HIV-infected persons.
The routine use of direct virus assays e. Whether extended follow-up is indicated in other circumstances e. The same principles of exposure management could be applied to other workers who have potential for occupational exposure to blood and body fluids in other settings.
HBIG is not contraindicated for pregnant or lactating women. When HIV infection is identified, the person should be referred to a specialist knowledgeable in the area of HIV treatment and counseling for medical management.Recent experience with post-exposure prophylaxis (PEP) with combination antiretrovirals for occupational exposure (OE) to HIV [Abstract ].
In: Program and abstracts of the 35th annual meeting of the Infectious Diseases Society of America.
Federal and best-practice recommendations for post-exposure prophylaxis (PEP) decisions. The following guidelines and guidances from U.S.P.H.S, the CDC, and current literature provide information on identifying, managing, and following up on potential exposures to HIV and hepatitis B and C.
Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Post Exposure Prophylaxis Issues. Animal Studies of PEP Efficacy • Seroconversion infrequent following occupational exposure to HIV-infected blood • Study of converters vs nonconverters showed use.
Post Exposure Prophylaxis (PEP) - NACO Guidelines "Post exposure prophylaxis" (PEP) refers to the comprehensive management given to minimize the risk of infection following potential exposure to blood-borne pathogens (HIV. The National Clinicians' Post-Exposure Prophylaxis Hotline (PEPline) Recommendations for the Management of HCP Potentially Exposed to HIV.
CDC. Updated U.S. Public Health Service guidelines for the management of occupational exposures to HBV, HCV, and HIV and recommendations for postexposure prophylaxis. Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis.
Hepatitis B Virus (HBV), Hepatitis C Post Exposure Prophylaxis Issues. Animal Studies of PEP Efficacy • Data have been difficult to interpret and.Download